Investigating the genetic association between ERAP1 and ankylosing spondylitis.
|Abstract||A strong association between ERAP1 and ankylosing spondylitis (AS) was recently identified by the Wellcome Trust Case Control Consortium and the Australo-Anglo-American Spondylitis Consortium (WTCCC-TASC) study. ERAP1 is highly polymorphic with strong linkage disequilibrium evident across the gene. We therefore conducted a series of experiments to try to identify the primary genetic association(s) with ERAP1. We replicated the original associatio ... [truncated at 450 characters in length]|
|Author||Harvey, David; Pointon, Jennifer J; Evans, David M; et al|
|Subject||Aminopeptidases Case-Control Studies Cohort Studies Gene Frequency Genetic Predisposition to Disease Genotype Humans Linkage Disequilibrium Logistic Models Models, Molecular Polymorphism, Single Nucleotide Protein Conformation Protein Structure, Tertiary Sequence Analysis, DNA Spondylitis, Ankylosing chemistry genetics genetics|