The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.
|Abstract||Short-chain dehydrogenases/reductases (SDR) constitute one of the largest enzyme superfamilies with presently over 46,000 members. In phylogenetic comparisons, members of this superfamily show early divergence where the majority have only low pairwise sequence identity, although sharing common structural properties. The SDR enzymes are present in virtually all genomes investigated, and in humans over 70 SDR genes have been identified. In humans, ... [truncated at 450 characters in length]|
|Author||Persson, Bengt; Kallberg, Yvonne; Bray, James E; et al|
|Subject||Internet Markov Chains Oxidoreductases Acting on CH-CH Group Donors Terminology as Topic|
The human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summary.
|Abstract||The short-chain dehydrogenase/reductase (SDR) superfamily represents one of the largest protein superfamilies known to date. Enzymes of this family usually catalyse NAD(P)(H) dependent reactions with a substrate spectrum ranging from polyols, retinoids, steroids and fatty acid derivatives to xenobiotics. We have currently identified 73 SDR superfamily members within the human genome. A status report of the human SDR superfamily is provided in ter ... [truncated at 450 characters in length]|
|Author||Bray, James E; Marsden, Brian D; Oppermann, Udo;|
|Subject||Computational Biology Models, Molecular Oxidoreductases Acting on CH-CH Group Donors Protein Conformation Structure-Activity Relationship chemistry genetics metabolism|