Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy.
|Abstract||The bisphosphonates (BPs) are well established as the treatments of choice for disorders of excessive bone resorption, including Paget's disease of bone, myeloma and bone metastases, and osteoporosis. There is considerable new knowledge about how BPs work. Their classical pharmacological effects appear to result from two key properties: their affinity for bone mineral and their inhibitory effects on osteoclasts. Mineral binding affinities differ ... [truncated at 450 characters in length]|
|Author||Russell, R Graham G; Xia, Zhidao; Dunford, James E; et al|
|Subject||Animals Bone Neoplasms Bone Resorption Bone and Bones Diphosphonates Guanosine Triphosphate Humans Models, Biological Models, Chemical Multiple Myeloma Neoplasm Metastasis Nitrogen Osteoclasts Osteocytes Osteoporosis Protein Processing, Post-Translational T-Lymphocytes Treatment Outcome secondary metabolism chemistry pharmacology therapeutic use chemistry metabolism chemistry metabolism metabolism therapy metabolism|