This thesis describes investigations into the use of electrochemical oxidation as a method for the activation of glycosyl donors, and in particular the application of this technique to the selective activation of one electrochemically active glycoside over another.
The synthesis of twenty eight electrochemically active monosaccharide donors, including thio-, seleno- and O-glycosides with varying protecting group patterns and a ... [truncated at 450 characters in length]
|Subject||Oligosaccharides Synthesis Electrolytic oxidation|
This thesis is concerned with structural aspects of the recognition and effector functions of antibody molecules. The recognition process is investigated in the dinitrophenyl (DNP) binding mouse IgA produced by the myeloma MOPC 315. The studies on effector functions utilize a DNP binding mouse hybridoma IgG2a to examine the role of N-glycosylation in IgG.
The combining site of protein 315. The involvement of tyrosyl residues i ... [truncated at 450 characters in length]
|Author||Leatherbarrow, Robin J.;|
|Subject||Glycosylation Oligosaccharides DNA-binding proteins Dinitrobenzenes|
|Author||Field, Mark C.;|
|Subject||Oligosaccharides Structure Glycoproteins Immunoglobulins Serum Nervous system|
This thesis describes investigations into the possibility and scope of allylderived intramolecular aglycon delivery as a tool for the stereospecific formation of 1,2-cis glycosides. The three-step procedure involves isomerisation of the 2-O-allyl protection of a glycosyl donor, followed by iodonium-mediated tethering to an aglycon alcohol. Activation of the donor induces intramolecular delivery of the aglycon, to afford the 1,2-ci ... [truncated at 450 characters in length]
|Subject||Oligosaccharides Synthesis Glycosides|