This thesis investigates rest-activity and sleep profiles in neurodegeneration and brain cancer. Study 1 comprised longitudinal field assessments of rest-activity, sleep and memory in controls and memory-impairment individuals with: subjective memory complaint (SMC), amnestic mild cognitive impairment (aMCI), mild and moderate Alzheimer’s disease (AD). Four questions were addressed: (1) is SMC a prodromal stage of AD? (2) do characteristics of ... [truncated at 450 characters in length]
|Creator||Emma J Wams;|
|Subject||Medical Sciences Biology (medical sciences) Geratology Ophthamology Tumours Cognitive Neuroscience Neuropathology Old Age psychiatry Memory Cognition Oncology|
The aim of the research presented in this thesis was to improve the characterisation of the changes in brain structure and function that occur at different stages of Alzheimer’s disease (AD) progression, from pre-symptomatic AD, to mild cognitive impairment (MCI), to clinically evident dementia, using magnetic resonance imaging (MRI) techniques.
Baseline structural MRI data from a cohort of healthy older adults who were followed prospe ... [truncated at 450 characters in length]
|Subject||Geratology Neuroscience Old Age psychiatry Neurology|
Late-life depression (LLD) is common illness, frequently associated with neuropsychological impairment. Disruption of frontal-subcortical and limbic networks may play a key role in LLD and can be examined using magnetic resonance imaging (MRI). Grey matter (GM) can be examined using T1-weighted MRI, white matter (WM) using diffusion tensor imaging (DTI), and functional connectivity using resting-state functional MRI (fMRI).
To clarify th ... [truncated at 450 characters in length]
|Creator||Claire Elizabeth Sexton;|
|Subject||Old Age psychiatry Psychiatry|
|Abstract||Background: The cognitive impairment of older depressed patients with late- as opposed to early-onset illness may show important differences, in that patients with early onset may suffer predominantly from impaired episodic memory, and those with late onset mainly from reductions of executive function and processing speed. Method: We searched Medline and EMBASE as well as individual papers' reference lists for relevant publications, recording com ... [truncated at 450 characters in length]|
|Author||Lucie L. Herrmann; Guy M. Goodwin; Klaus P. Ebmeier;|
|Subject||Psychiatry Old Age psychiatry|
|Abstract||Background: There have been increasing concerns regarding the safety and efficacy of neuroleptics in people with dementia, but there are very few long-term trials to inform clinical practice. The aim of this study was to determine the impact of long-term treatment with neuroleptic agents upon global cognitive decline and neuropsychiatric symptoms in patients with Alzheimer disease. Methods and findings. Design: randomised, blinded, placebo-contro ... [truncated at 450 characters in length]|
|Author||Clive Ballard; Marisa Margallo Lana; Megan Theodoulou; et al|
|Subject||Medical sciences Psychiatry Old Age psychiatry Statistics (see also social sciences)|