Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology.
|Abstract||Carbonyl groups are frequently found in endogenous or xenobiotic compounds. Reactive carbonyls, formed during lipid peroxidation or food processing, and xenobiotic quinones are able to covalently modify DNA or amino acids. They can also promote oxidative stress, the products of which are thought to be an important initiating factor in degenerative diseases or cancer. Carbonyl groups are reduced by an array of distinct NADPH-dependent enzymes, bel ... [truncated at 450 characters in length]|
|Subject||Alcohol Oxidoreductases Animals Humans Mammals NADH, NADPH Oxidoreductases Oxidative Stress Quinones Structure-Activity Relationship Xenobiotics metabolism physiology metabolism metabolism|