ENU mouse mutant with a hypomorphic mutation in DNA ligase IV
|Subject||Mice Abnormalities Genetic aspects DNA ligases Mutagenesis|
Structural basis for substrate specificity in human monomeric carbonyl reductases.
|Abstract||Carbonyl reduction constitutes a phase I reaction for many xenobiotics and is carried out in mammals mainly by members of two protein families, namely aldo-keto reductases and short-chain dehydrogenases/reductases. In addition to their capacity to reduce xenobiotics, several of the enzymes act on endogenous compounds such as steroids or eicosanoids. One of the major carbonyl reducing enzymes found in humans is carbonyl reductase 1 (CBR1) with a v ... [truncated at 450 characters in length]|
|Author||Pilka, Ewa S; Niesen, Frank H; Lee, Wen Hwa; et al|
|Subject||Alcohol Oxidoreductases Antineoplastic Agents Cloning, Molecular Crystallography, X-Ray Ethanolamines Humans Isoquinolines Kinetics Mutagenesis Mutagenesis, Site-Directed Structure-Activity Relationship Substrate Specificity Temperature Xenobiotics chemistry pharmacology methods chemistry chemistry chemistry|