Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector.
|Abstract||Regulator of G-protein signaling (RGS) proteins have been well-described as accelerators of Galpha-mediated GTP hydrolysis ("GTPase-accelerating proteins" or GAPs). However, RGS proteins with complex domain architectures are now known to regulate much more than Galpha GTPase activity. RGS14 contains tandem Ras-binding domains that have been reported to bind to Rap- but not Ras GTPases in vitro, leading to the suggestion that RGS14 is a Rap-specif ... [truncated at 450 characters in length]|
|Author||Willard, Francis S; Willard, Melinda D; Kimple, Adam J; et al|
|Subject||Animals Binding Sites Cell Differentiation Extracellular Signal-Regulated MAP Kinases Fibroblast Growth Factor 2 Humans Mice Mitogen-Activated Protein Kinases Multiprotein Complexes Nerve Growth Factor Neurites PC12 Cells Protein Binding RGS Proteins Rats raf Kinases ras Proteins antagonists and inhibitors physiology antagonists and inhibitors physiology physiology metabolism|
Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation.
|Abstract||Vitamin B(12) (cobalamin, Cbl) is essential to the function of two human enzymes, methionine synthase (MS) and methylmalonyl-CoA mutase (MUT). The conversion of dietary Cbl to its cofactor forms, methyl-Cbl (MeCbl) for MS and adenosyl-Cbl (AdoCbl) for MUT, located in the cytosol and mitochondria, respectively, requires a complex pathway of intracellular processing and trafficking. One of the processing proteins, MMAA (methylmalonic aciduria type ... [truncated at 450 characters in length]|
|Author||Froese, D Sean; Kochan, Grazyna; Muniz, João R C; et al|
|Subject||Child Child, Preschool Cobamides Crystallography, X-Ray Cytosol Guanosine Diphosphate Guanosine Triphosphate Humans Membrane Transport Proteins Metabolism, Inborn Errors Methylmalonyl-CoA Mutase Mitochondria Mitochondrial Proteins Multiprotein Complexes Mutation, Missense Protein Structure, Quaternary chemistry genetics metabolism chemistry metabolism chemistry genetics metabolism chemistry genetics metabolism chemistry genetics metabolism chemistry genetics metabolism chemistry genetics metabolism chemistry genetics metabolism chemistry genetics metabolism|