Targeting group II PAKs in cancer and metastasis.
|Abstract||The p21 activated kinases (PAKs) play an essential role in cell signaling and control a variety of cellular functions including cell motility, survival, angiogenesis and mitosis. PAKs are important regulators in growth factor signaling, cytoskeletal reorganization and growth factor-mediated cell migration. Overexpression of PAKs has been detected in many cancers and linked to increased migration potential, anchorage independent growth and metasta ... [truncated at 450 characters in length]|
|Author||Eswaran, Jeyanthy; Soundararajan, Meera; Knapp, Stefan;|
|Subject||Animals Antineoplastic Agents Apoptosis Cell Transformation, Neoplastic Chemistry, Pharmaceutical Crystallography, X-Ray Cytoskeleton Drug Design Gene Expression Regulation, Neoplastic Humans Mitosis Neoplasm Metastasis Neoplasms Neurons p21-Activated Kinases pharmacology methods methods metabolism metabolism pathology metabolism metabolism|