Dynamic protein methylation in chromatin biology.
|Abstract||Post-translational modification of chromatin is emerging as an increasingly important regulator of chromosomal processes. In particular, histone lysine and arginine methylation play important roles in regulating transcription, maintaining genomic integrity, and contributing to epigenetic memory. Recently, the use of new approaches to analyse histone methylation, the generation of genetic model systems, and the ability to interrogate genome wide h ... [truncated at 450 characters in length]|
|Author||Ng, S S; Yue, W W; Oppermann, U; et al|
|Subject||Animals Arginine Chromatin DNA Damage Embryonic Stem Cells Epigenesis, Genetic Gene Expression Regulation Germ Cells Histone-Lysine N-Methyltransferase Histones Lysine Methylation Models, Molecular Molecular Structure Neoplasms Oxidoreductases, N-Demethylating Protein Conformation Protein Methyltransferases Protein Processing, Post-Translational Tumor Suppressor Protein p53 metabolism metabolism physiology physiology genetics metabolism metabolism genetics metabolism genetics metabolism chemistry genetics metabolism genetics metabolism|
A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics.
|Abstract||Methylation of lysine residues on the tails of histone proteins is a major determinant of the transcription state of associated DNA coding regions. The interplay among methylation states and other histone modifications to direct transcriptional outcome is referred to as the histone code. In addition to histone methyltransferases and demethylases which function to modify the methylation state of lysine sidechains, other proteins recognize specific ... [truncated at 450 characters in length]|
|Author||Quinn, Amy M; Bedford, Mark T; Espejo, Alexsandra; et al|
|Subject||Binding, Competitive Chemiluminescent Measurements Chromosomal Proteins, Non-Histone Epigenesis, Genetic Histones Lysine Methylation Peptides Phosphoproteins Protein Interaction Domains and Motifs Protein Interaction Mapping chemistry metabolism chemistry metabolism metabolism metabolism chemistry metabolism methods|