The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.
|Abstract||Short-chain dehydrogenases/reductases (SDR) constitute one of the largest enzyme superfamilies with presently over 46,000 members. In phylogenetic comparisons, members of this superfamily show early divergence where the majority have only low pairwise sequence identity, although sharing common structural properties. The SDR enzymes are present in virtually all genomes investigated, and in humans over 70 SDR genes have been identified. In humans, ... [truncated at 450 characters in length]|
|Author||Persson, Bengt; Kallberg, Yvonne; Bray, James E; et al|
|Subject||Internet Markov Chains Oxidoreductases Acting on CH-CH Group Donors Terminology as Topic|
Classification of the short-chain dehydrogenase/reductase superfamily using hidden Markov models.
|Abstract||The short-chain dehydrogenase/reductase (SDR) superfamily now has over 47 000 members, most of which are distantly related, with typically 20-30% residue identity in pairwise comparisons, making it difficult to obtain an overview of this superfamily. We have therefore developed a family classification system, based upon hidden Markov models (HMMs). To this end, we have identified 314 SDR families, encompassing about 31,900 members. In addition, a ... [truncated at 450 characters in length]|
|Author||Kallberg, Yvonne; Oppermann, Udo; Persson, Bengt;|
|Subject||Animals Archaea Bacteria Cluster Analysis Computational Biology Databases, Protein Eukaryota Genome Humans Markov Chains Mice Oxidoreductases Rats Sequence Alignment enzymology genetics enzymology genetics methods enzymology genetics genetics classification genetics|