Structure of dystrophia myotonica protein kinase.
|Abstract||Dystrophia myotonica protein kinase (DMPK) is a serine/threonine kinase composed of a kinase domain and a coiled-coil domain involved in the multimerization. The crystal structure of the kinase domain of DMPK bound to the inhibitor bisindolylmaleimide VIII (BIM-8) revealed a dimeric enzyme associated by a conserved dimerization domain. The affinity of dimerisation suggested that the kinase domain alone is insufficient for dimerisation in vivo and ... [truncated at 450 characters in length]|
|Author||Elkins, Jonathan M; Amos, Ann; Niesen, Frank H; et al|
|Subject||Amino Acid Sequence Animals Crystallography, X-Ray Humans Indoles Maleimides Molecular Sequence Data Protein Binding Protein Conformation Protein Interaction Domains and Motifs Protein Multimerization Protein-Serine-Threonine Kinases chemistry metabolism chemistry metabolism chemistry metabolism|