Neonatal alloimmune thrombocytopenia (NAIT) is caused by maternal alloantibodies against fetal platelet antigens inherited from the father and which are absent from maternal platelets. In Caucasians, antibodies against the Leu33 (HPA-1a) polymorphism of integrin β3 (part of the platelet αIIbβ3 complex) account for >70% of cases. Antenatal screening for these antibodies does not currently take place in the UK, partly because of the absence of s ... [truncated at 450 characters in length]
|Creator||David L Allen;|
|Subject||Clinical laboratory sciences Blood Immunodiagnostics Immunology|
An individual's Human Leukocyte Antigen (HLA) type is an essential immunogenetic parameter, influencing susceptibility to a variety of autoimmune and infectious diseases, to certain types of cancer and the likelihood of adverse drug reactions.
I present and evaluate two models for the accurate statistical determination of HLA types for single-population and multi-population studies, based on SNP genotypes. Importantly, SNP genotypes are ... [truncated at 450 characters in length]
|Creator||Alexander Tilo Dilthey;|
|Subject||Genetics (life sciences) Bioinformatics (life sciences) Immunodiagnostics Immunology Mathematical genetics and bioinformatics (statistics) Statistics (see also social sciences)|