SDR-type human hydroxysteroid dehydrogenases involved in steroid hormone activation.
|Abstract||Hydroxysteroid dehydrogenases catalyze the NAD(P)(H)-dependent oxidoreduction of hydroxyl and oxo-functions at distinct positions of steroid hormones. This reversible reaction constitutes an important pre-receptor control mechanism for nuclear receptor ligands of the androgen, estrogen and glucocorticoid classes, since the conversion "switches" between receptor ligands and their inactive metabolites. The major reversible activities found in mamma ... [truncated at 450 characters in length]|
|Author||Wu, Xiaoqiu; Lukacik, Petra; Kavanagh, Kathryn L; et al|
|Subject||Hormones Humans Hydroxysteroid Dehydrogenases Isoenzymes Models, Molecular Steroids metabolism chemistry metabolism chemistry metabolism metabolism|
A non-enzymatic function of 17beta-hydroxysteroid dehydrogenase type 10 is required for mitochondrial integrity and cell survival.
|Abstract||Deficiency of the mitochondrial enzyme 2-methyl-3-hydroxybutyryl-CoA dehydrogenase involved in isoleucine metabolism causes an organic aciduria with atypical neurodegenerative course. The disease-causing gene is HSD17B10 and encodes 17beta-hydroxysteroid dehydrogenase type 10 (HSD10), a protein also implicated in the pathogenesis of Alzheimer's disease. Here we show that clinical symptoms in patients are not correlated with residual enzymatic act ... [truncated at 450 characters in length]|
|Author||Rauschenberger, Katharina; Schöler, Katja; Sass, Jörn Oliver; et al|
|Subject||3-Hydroxyacyl CoA Dehydrogenases Animals Apoptosis Cell Survival Cells, Cultured Fibroblasts Gene Deletion Genetic Complementation Test Humans Hydroxysteroid Dehydrogenases Infant Mice Mice, Knockout Mitochondria Models, Molecular Neurons Protein Structure, Tertiary Xenopus deficiency metabolism metabolism ultrastructure deficiency metabolism physiology ultrastructure physiology|