Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.
|Abstract||3-Hydroxy-3-methylglutaryl coenzyme A (CoA) synthase (HMGCS) catalyzes the condensation of acetyl-CoA and acetoacetyl-CoA into 3-hydroxy-3-methylglutaryl CoA. It is ubiquitous across the phylogenetic tree and is broadly classified into three classes. The prokaryotic isoform is essential in Gram-positive bacteria for isoprenoid synthesis via the mevalonate pathway. The eukaryotic cytosolic isoform also participates in the mevalonate pathway but it ... [truncated at 450 characters in length]|
|Author||Shafqat, Naeem; Turnbull, Andrew; Zschocke, Johannes; et al|
|Subject||Crystallography, X-Ray Dimerization Humans Hydroxymethylglutaryl-CoA Synthase Ketones Models, Molecular Mutation, Missense Protein Isoforms Protein Structure, Quaternary antagonists and inhibitors chemistry deficiency genetics metabolism antagonists and inhibitors chemistry deficiency genetics|