The phototransposition reactions of thiophene- carbonitriles were shown to occur via the intermediate formation and isomerisation of 5-thiabicyclo[2˙1˙0]pent- 2-enes . Thus, irradiation of thiophene-3-carbonitrile in cyclohexane gave 5-thiabieyelo[2˙1˙0]pent-2-ene-2-carbonitrile as the primary photochemical product. Further irradiation produced thiophene-2-carbonitrile. The reaction was reversible, Addition of furan to 5-thiabicyclo[ ... [truncated at 450 characters in length]
|Subject||Heterocyclic compounds Photochemistry|
This thesis is concerned with studies towards the total synthesis of a class of natural products - the oxazolomycins. Attention was focused on the left-hand side triene fragment and right-hand side lactam heterocyclic system.
This thesis describes the synthesis of a racemic terminal phenyl analogue of oxazolomycin A and C, possessing the left-hand side triene geometry as required. A novel truncated pyridine analogue is also described. Th ... [truncated at 450 characters in length]
|Author||Trippier, Paul Charles.;|
|Subject||Heterocyclic compounds Bioactive compounds|