Structure and substrate specificity of the Pim-1 kinase.
|Abstract||The Pim kinases are a family of three vertebrate protein serine/threonine kinases (Pim-1, -2, and -3) belonging to the CAMK (calmodulin-dependent protein kinase-related) group. Pim kinases are emerging as important mediators of cytokine signaling pathways in hematopoietic cells, and they contribute to the progression of certain leukemias and solid tumors. A number of cytoplasmic and nuclear proteins are phosphorylated by Pim kinases and may act a ... [truncated at 450 characters in length]|
|Author||Bullock, Alex N; Debreczeni, Judit; Amos, Ann L; et al|
|Subject||Amino Acid Motifs Arginine Binding Sites Biotinylation Calcium-Calmodulin-Dependent Protein Kinase Type 1 Calcium-Calmodulin-Dependent Protein Kinases Calorimetry Cell Nucleus Crystallography, X-Ray Cytoplasm Glycine Hematopoietic Stem Cells Humans Kinetics Models, Molecular Peptide Library Peptide Nucleic Acids Peptides Phosphorylation Protein Binding Protein Conformation Protein Isoforms Protein Structure, Tertiary Protein-Serine-Threonine Kinases Proto-Oncogene Proteins Proto-Oncogene Proteins c-pim-1 Substrate Specificity chemistry metabolism metabolism metabolism chemistry metabolism chemistry chemistry metabolism physiology physiology metabolism physiology|