Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase.
|Abstract||The c-KIT receptor tyrosine kinase mediates the cellular response to stem cell factor (SCF). Whereas c-KIT activity is important for the proliferation of hematopoietic cells, melanocytes and germ cells, uncontrolled c-KIT activity contributes to the growth of diverse human tumors. Suppressor of cytokine signaling 6 (SOCS6) is a member of the SOCS family of E3 ubiquitin ligases that can interact with c-KIT and suppress c-KIT-dependent pathways. He ... [truncated at 450 characters in length]|
|Author||Zadjali, Fahad; Pike, Ashley C W; Vesterlund, Mattias; et al|
|Subject||Amino Acid Sequence HEK293 Cells Humans Models, Molecular Molecular Sequence Data Phosphopeptides Protein Tyrosine Phosphatase, Non-Receptor Type 11 Proto-Oncogene Proteins c-kit Signal Transduction Stem Cell Factor Substrate Specificity Suppressor of Cytokine Signaling Proteins Ubiquitination src Homology Domains metabolism chemistry metabolism antagonists and inhibitors metabolism metabolism chemistry metabolism|