Modeling of an ion channel in its open conformation.
|Abstract||We have modeled the structure of KirBac1.1 in an open state using as a starting point the structure of KirBac1.1 in its closed conformation (Protein Data Bank 1P7B). To test the validity of the open-state model, molecular dynamics simulations in octane, a lipid bilayer mimetic, were carried out. Simulations of the closed conformer were used for comparison purposes. The total simulation time was approximately 138 ns. The initial open model was ref ... [truncated at 450 characters in length]|
|Author||Domene, Carmen; Doyle, Declan A; Vénien-Bryan, Catherine;|
|Subject||Biophysics Burkholderia pseudomallei Crystallography, X-Ray Databases, Protein Glycine Models, Molecular Phenylalanine Potassium Potassium Channels, Inwardly Rectifying Protein Conformation Protein Structure, Secondary methods metabolism chemistry chemistry chemistry chemistry|
Structure and substrate specificity of the Pim-1 kinase.
|Abstract||The Pim kinases are a family of three vertebrate protein serine/threonine kinases (Pim-1, -2, and -3) belonging to the CAMK (calmodulin-dependent protein kinase-related) group. Pim kinases are emerging as important mediators of cytokine signaling pathways in hematopoietic cells, and they contribute to the progression of certain leukemias and solid tumors. A number of cytoplasmic and nuclear proteins are phosphorylated by Pim kinases and may act a ... [truncated at 450 characters in length]|
|Author||Bullock, Alex N; Debreczeni, Judit; Amos, Ann L; et al|
|Subject||Amino Acid Motifs Arginine Binding Sites Biotinylation Calcium-Calmodulin-Dependent Protein Kinase Type 1 Calcium-Calmodulin-Dependent Protein Kinases Calorimetry Cell Nucleus Crystallography, X-Ray Cytoplasm Glycine Hematopoietic Stem Cells Humans Kinetics Models, Molecular Peptide Library Peptide Nucleic Acids Peptides Phosphorylation Protein Binding Protein Conformation Protein Isoforms Protein Structure, Tertiary Protein-Serine-Threonine Kinases Proto-Oncogene Proteins Proto-Oncogene Proteins c-pim-1 Substrate Specificity chemistry metabolism metabolism metabolism chemistry metabolism chemistry chemistry metabolism physiology physiology metabolism physiology|