Probing the structural basis of RecQ helicase function.
|Abstract||RecQ helicases are a ubiquitous family of DNA unwinding enzymes required to preserve genome integrity, thus preventing premature aging and cancer formation. The five human representatives of this family play non-redundant roles in the suppression of genome instability using a combination of enzymatic activities that specifically characterize each member of the family. These enzymes are in fact not only able to catalyze the transient opening of DN ... [truncated at 450 characters in length]|
|Author||Vindigni, Alessandro; Marino, Francesca; Gileadi, Opher;|
|Subject||DNA Repair DNA Replication DNA, Cruciform Genomic Instability Humans Protein Structure, Tertiary RecQ Helicases chemistry metabolism chemistry metabolism|