|Subject||Drosophila melanogaster Genetics Mannosidases Glycosylation|
Development of safe and efficient approaches for gene delivery in human embryonic stem cells (hESc) and particularly in human induced pluripotent stem (hiPS) cells, which can be derived in a person-specific manner, is considered to be imperative for harnessing their full potential in both the basic and applied research. The aim of this study was to evaluate the potential of human artificial chromosome (HAC) for gene delivery and expression in ... [truncated at 450 characters in length]
|Subject||Medical Sciences Genetics Stem cells|
Throughout the range of the common shrew (Sorex araneus Linnaeus 1767), repeated Robertsonian fusion mutations have led to a karyotypic polymorphism dividing the species into chromosome races. Studies of fertility were undertaken in the male, both of homozygotes and of heterozygotes forming meiotic multivalents of varying complexity.
Observations made at pachytene, diakinesis/metaphase I and metaphase II did not provide eviden ... [truncated at 450 characters in length]
|Author||Mercer, Simon John.;|
|Subject||Common shrew Genetics Fertility|
This thesis is a genetic study of the cytoplasmically- inherited determinant [psi] of Saccharomyces cerevisiae . [psi] is a potentiator of ochre suppression. The molecular basis of [psi] was investigated using mutagenesis as a probe. The psi+ phenotype (efficient suppression) can be mutated to psi- phenotype (loss of suppression) by ultra-violet light (UV) and nitrosoguanidine (NTG) . The UV-induced mut ... [truncated at 450 characters in length]
|Author||Tuite, M. F.;|
|Subject||Saccharomyces cerevisiae Genetics Yeast|
Experiments designed to study the movement of genes between the plasmids and the chromosome of Staphylococcus aureus are described.
Two derivatives of the plasmid pI9789::Tn552, that are temperature-sensitive for replication, pSl and pAD, are used as a model system for this investigation. The plasmids carry a gene conferring resistance to cadmium salts and so the number of cadmium-resistant colonies appearing on selective plates ... [truncated at 450 characters in length]
|Subject||Plasmids Genetics Chromosomes Staphylococcus aureus|