The centaurin gamma-1 GTPase-like domain functions as an NTPase.
|Abstract||Centaurins are a family of proteins that contain GTPase-activating protein domains, with the gamma family members containing in addition a GTPase-like domain. Centaurins reside mainly in the nucleus and are known to activate phosphoinositide 3-kinase, a key regulator of cell proliferation, motility and vesicular trafficking. In the present study, using X-ray structural analysis, enzymatic assays and nucleotide-binding studies, we show that, for C ... [truncated at 450 characters in length]|
|Author||Soundararajan, Meera; Yang, Xiaowen; Elkins, Jonathan M; et al|
|Subject||Amino Acid Sequence Binding Sites Cloning, Molecular Escherichia coli GTP-Binding Proteins GTPase-Activating Proteins Hydrolysis Models, Molecular Molecular Structure Nucleoside-Triphosphatase Nucleotides Protein Structure, Tertiary Signal Transduction Substrate Specificity ras Proteins metabolism chemistry metabolism chemistry metabolism chemistry metabolism metabolism chemistry metabolism|