Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases.
|Abstract||Sirtuins are a family of protein lysine deacetylases, which regulate gene silencing, metabolism, life span, and chromatin structure. Sirtuins utilize NAD(+) to deacetylate proteins, yielding O-acetyl-ADP-ribose (OAADPr) as a reaction product. The macrodomain is a ubiquitous protein module known to bind ADP-ribose derivatives, which diverged through evolution to support many different protein functions and pathways. The observation that some sirtu ... [truncated at 450 characters in length]|
|Author||Chen, Dawei; Vollmar, Melanie; Rossi, Marianna N; et al|
|Subject||Escherichia coli Escherichia coli Proteins Evolution, Molecular Fungal Proteins Hela Cells Humans Neurospora crassa Protein Structure, Tertiary Sirtuins Staphylococcus aureus enzymology genetics chemistry genetics metabolism chemistry genetics metabolism enzymology genetics chemistry genetics metabolism enzymology genetics|