Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.
|Abstract||All eukaryotic cellular mRNAs contain a 5' m(7)GpppN cap. In addition to conferring stability to the mRNA, the cap is required for pre-mRNA splicing, nuclear export and translation by providing an anchor point for protein binding. In translation, the interaction between the cap and the eukaryotic initiation factor 4E (eIF4E) is important in the recruitment of the mRNAs to the ribosome. Human 4EHP (h4EHP) is a homologue of eIF4E. Like eIF4E it is ... [truncated at 450 characters in length]|
|Author||Rosettani, Pamela; Knapp, Stefan; Vismara, Maria-Grazia; et al|
|Subject||Amino Acid Sequence Binding Sites Calorimetry Conserved Sequence Crystallography, X-Ray Eukaryotic Initiation Factor-4E Evolution, Molecular Guanosine Triphosphate Humans Models, Molecular Molecular Sequence Data Mutation Peptides Protein Binding RNA Cap-Binding Proteins RNA Caps chemistry genetics metabolism chemistry metabolism chemistry chemistry genetics metabolism chemistry|