Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.
|Abstract||The mammalian SPRY domain- and SOCS box-containing proteins, SPSB1 to SPSB4, belong to the SOCS box family of E3 ubiquitin ligases. Substrate recognition sites for the SPRY domain are identified only for human Par-4 (ELNNNL) and for the Drosophila orthologue GUSTAVUS binding to the DEAD-box RNA helicase VASA (DINNNN). To further investigate this consensus motif, we determined the crystal structures of SPSB1, SPSB2, and SPSB4, as well as their bin ... [truncated at 450 characters in length]|
|Author||Filippakopoulos, Panagis; Low, Andrew; Sharpe, Timothy D; et al|
|Subject||Amino Acid Motifs Amino Acid Sequence Animals Binding Sites Consensus Sequence Crystallography, X-Ray DEAD-box RNA Helicases Humans Magnetic Resonance Spectroscopy Mice Protein Binding Protein Conformation Receptors, Thrombin Suppressor of Cytokine Signaling Proteins chemistry metabolism chemistry metabolism chemistry metabolism|