The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.
|Abstract||The positive transcription elongation factor b (P-TEFb) (CDK9/cyclin T (CycT)) promotes mRNA transcriptional elongation through phosphorylation of elongation repressors and RNA polymerase II. To understand the regulation of a transcriptional CDK by its cognate cyclin, we have determined the structures of the CDK9/CycT1 and free cyclin T2. There are distinct differences between CDK9/CycT1 and the cell cycle CDK CDK2/CycA manifested by a relative r ... [truncated at 450 characters in length]|
|Author||Baumli, Sonja; Lolli, Graziano; Lowe, Edward D; et al|
|Subject||Amino Acid Sequence Animals Binding Sites Cyclin T Cyclin-Dependent Kinase 9 Cyclins Flavonoids Humans Models, Molecular Molecular Sequence Data Phosphorylation Piperidines Sequence Alignment chemistry metabolism chemistry metabolism metabolism metabolism|