Crystallisation kinetics and optical properties of Ge₂Sb₂Te₅
|Abstract||This thesis reports on the work carried out by the author on the crystallisation kinetics and optical properties of thin amorphous Ge₂Sb₂Te₅ films. This study is prompted by the application of these films in optical phase change recording media. The work is partly theoretical and partly experimental in nature. Starting from the general nucleation and growth theory, it was shown that the Johnson-Mehl-Avrami-Kolmogorov (JMAK) equations are equally ... [truncated at 450 characters in length]|
Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease.
|Abstract||Refsum disease (RD), a neurological syndrome characterized by adult onset retinitis pigmentosa, anosmia, sensory neuropathy, and phytanic acidaemia, is caused by elevated levels of phytanic acid. Many cases of RD are associated with mutations in phytanoyl-CoA 2-hydroxylase (PAHX), an Fe(II) and 2-oxoglutarate (2OG)-dependent oxygenase that catalyzes the initial alpha-oxidation step in the degradation of phytenic acid in peroxisomes. We describe t ... [truncated at 450 characters in length]|
|Author||McDonough, Michael A; Kavanagh, Kathryn L; Butler, Danica; et al|
|Subject||Aspartic Acid Binding Sites Coenzyme A Crystallization Crystallography, X-Ray Cysteine Escherichia coli Ferrous Compounds Histidine Humans Ketoglutaric Acids Mixed Function Oxygenases Models, Molecular Mutation Peroxisomes Phytanic Acid Protein Binding Protein Structure, Secondary Recombinant Proteins Refsum Disease Structure-Activity Relationship Transfection metabolism genetics metabolism metabolism genetics metabolism metabolism metabolism chemistry genetics enzymology analogs and derivatives metabolism drug therapy enzymology|
The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding.
|Abstract||Modification of GTPases with isoprenoid molecules derived from geranylgeranyl pyrophosphate or farnesyl pyrophosphate is an essential requisite for cellular signaling pathways. The synthesis of these isoprenoids proceeds in mammals through the mevalonate pathway, and the final steps in the synthesis are catalyzed by the related enzymes farnesyl pyrophosphate synthase and geranylgeranyl pyrophosphate synthase. Both enzymes play crucial roles in ce ... [truncated at 450 characters in length]|
|Author||Kavanagh, Kathryn L; Dunford, James E; Bunkoczi, Gabor; et al|
|Subject||Crystallization Crystallography, X-Ray Dimerization Enzyme Inhibitors Feedback, Physiological Geranylgeranyl-Diphosphate Geranylgeranyltransferase Humans Kinetics Molecular Motor Proteins Protein Binding Protein Conformation antagonists and inhibitors chemistry chemistry|
X-ray crystallography of agonist/antagonist-bound receptors.
|Abstract||Crystallographic analysis of the ligand-binding domains of nuclear hormone receptors (NR) has provided a unique insight into the molecular events that underlie the ligand-mediated control of their transcriptional activity. The technique relies on preparing milligram quantities of protein, growing three-dimensional crystals of the desired protein-ligand complex, collecting X-ray diffraction data, and subsequently interpreting the derived electron ... [truncated at 450 characters in length]|
|Author||Pike, Ashley C W;|
|Subject||Crystallization Crystallography, X-Ray Estrogen Receptor alpha Ligands Protein Conformation Receptors, Cytoplasmic and Nuclear instrumentation methods instrumentation methods chemistry metabolism chemistry metabolism|