Differential regulation of CaMKII inhibitor beta protein expression after exposure to a novel context and during contextual fear memory formation.
|Abstract||Understanding of the molecular basis of long-term fear memory (fear LTM) formation provides targets in the treatment of emotional disorders. Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is one of the key synaptic molecules involved in fear LTM formation. There are two endogenous inhibitor proteins of CaMKII, CaMKII N alpha and N beta, which can regulate CaMKII activity in vitro. However, the physiological role of these endogenous inhibi ... [truncated at 450 characters in length]|
|Author||Radwańska, K; Tudor-Jones, A A; Mizuno, K; et al|
|Subject||Amygdala Animals Behavior, Animal Blotting, Western Calcium-Calmodulin-Dependent Protein Kinase Type 2 Conditioning, Classical Enzyme Inhibitors Fear Gene Expression Hippocampus Immunohistochemistry Memory Mice Mice, Inbred C57BL Olfactory Bulb Prosencephalon Up-Regulation metabolism antagonists and inhibitors genetics physiology metabolism physiology metabolism physiology metabolism metabolism|