Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.
|Abstract||Mps1, a dual-specificity kinase, is required for the proper functioning of the spindle assembly checkpoint and for the maintenance of chromosomal stability. As Mps1 function has been implicated in numerous phases of the cell cycle, the development of a potent, selective small-molecule inhibitor of Mps1 should facilitate dissection of Mps1-related biology. We describe the cellular effects and Mps1 cocrystal structures of new, selective small-molec ... [truncated at 450 characters in length]|
|Author||Kwiatkowski, Nicholas; Jelluma, Nannette; Filippakopoulos, Panagis; et al|
|Subject||Cell Cycle Cell Cycle Proteins Enzyme Inhibitors Models, Molecular Protein Kinase Inhibitors Protein-Serine-Threonine Kinases physiology pharmacology chemistry pharmacology physiology|