Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.
|Abstract||Long-term potentiation (LTP), a long-lasting enhancement in communication between neurons, is considered to be the major cellular mechanism underlying learning and memory. LTP triggers high-frequency calcium pulses that result in the activation of Calcium/Calmodulin (CaM)-dependent kinase II (CaMKII). CaMKII acts as a molecular switch because it remains active for a long time after the return to basal calcium levels, which is a unique property re ... [truncated at 450 characters in length]|
|Author||Rellos, Peter; Pike, Ashley C W; Niesen, Frank H; et al|
|Subject||Calcium Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calmodulin Calorimetry Catalytic Domain Enzyme Activation Humans Isoenzymes Models, Molecular Phosphorylation Phosphothreonine Protein Binding Protein Multimerization Protein Structure, Quaternary Protein Structure, Secondary Substrate Specificity metabolism chemistry metabolism chemistry metabolism antagonists and inhibitors chemistry metabolism metabolism|
Differential regulation of CaMKII inhibitor beta protein expression after exposure to a novel context and during contextual fear memory formation.
|Abstract||Understanding of the molecular basis of long-term fear memory (fear LTM) formation provides targets in the treatment of emotional disorders. Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is one of the key synaptic molecules involved in fear LTM formation. There are two endogenous inhibitor proteins of CaMKII, CaMKII N alpha and N beta, which can regulate CaMKII activity in vitro. However, the physiological role of these endogenous inhibi ... [truncated at 450 characters in length]|
|Author||Radwańska, K; Tudor-Jones, A A; Mizuno, K; et al|
|Subject||Amygdala Animals Behavior, Animal Blotting, Western Calcium-Calmodulin-Dependent Protein Kinase Type 2 Conditioning, Classical Enzyme Inhibitors Fear Gene Expression Hippocampus Immunohistochemistry Memory Mice Mice, Inbred C57BL Olfactory Bulb Prosencephalon Up-Regulation metabolism antagonists and inhibitors genetics physiology metabolism physiology metabolism physiology metabolism metabolism|