This thesis aimed to investigate the genetic basis of anxiety in mice. The first half describes searches for genetic variation beneath quantitative trait loci (QTLs) and computationally pulls together data from several sources in order to assess how likely each variant is to be responsible for the QTLs. The second half describes the results of the behavioural phenotyping of three knockout mouse models.
Examination of the sequence data b ... [truncated at 450 characters in length]
|Subject||Genetics (life sciences) Neuroscience Anxiety disorders|
|Author||Thorpe, Susan Jane.;|
|Subject||Anxiety disorders Diagnosis|
In this thesis, I investigate the genetics of neuropsychiatric disorders by analysing large data sets derived from high-throughput experiments, using novel comparative genomics approaches. In the first project, I explore characteristics of rare, de novo copy number variants identified among autism patients by employing various bioinformatics resources including Mouse Genome Informatics phenotypes, Gene Ontology terms, and protein-protein inter ... [truncated at 450 characters in length]
|Creator||Hyun Ji Noh;|
|Subject||Autism Anxiety disorders Bioinformatics (life sciences) Genetics (life sciences)|
Introduction: Physical inactivity is thought to contribute to the emergence of non-communicable diseases in post-conflict settings of low-income countries. Sport-for-development (SfD) organisations in these regions claim to improve the health of programme participants. However, there is a paucity of supporting evidence. I assessed the impact of a voluntary community-based SfD intervention on the physical activity (PA), physical fitness (PF) an ... [truncated at 450 characters in length]
|Creator||Justin A. Richards;|
|Subject||Cardiovascular disease Disease prevention Anxiety disorders Evidence based mental health Conflict Health (refugees) Psychosocial issues (refugees) Public Health Children and youth|
Catechol-O-methyltransferase (COMT) metabolises catechol-containing compounds, including dopamine. The aim of this thesis was to investigate whether COMT is involved in hippocampal function. This thesis also explored the role of functional polymorphisms within the COMT gene in the pathogenesis of schizophrenia and schizophrenia-related phenotypes.
First, as part of a study investigating the role of COMT in schizophrenia, human hippocampa ... [truncated at 450 characters in length]
|Creator||Linda Maria Laatikainen;|
|Subject||Medical sciences Biology (medical sciences) Genetics (medical sciences) Pharmacology Neuroscience Cognitive Neuroscience Neurogenetics Neuropsychology Psychiatry Anxiety disorders Bipolar disorder Cognitive therapy Molecular neuropathology Psychopharmacology Behavioural Neuroscience Cognition Experimental psychology Learning Memory Stress|