A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics.
|Abstract||Methylation of lysine residues on the tails of histone proteins is a major determinant of the transcription state of associated DNA coding regions. The interplay among methylation states and other histone modifications to direct transcriptional outcome is referred to as the histone code. In addition to histone methyltransferases and demethylases which function to modify the methylation state of lysine sidechains, other proteins recognize specific ... [truncated at 450 characters in length]|
|Author||Quinn, Amy M; Bedford, Mark T; Espejo, Alexsandra; et al|