Large-scale structural analysis of the classical human protein tyrosine phosphatome.
|Abstract||Protein tyrosine phosphatases (PTPs) play a critical role in regulating cellular functions by selectively dephosphorylating their substrates. Here we present 22 human PTP crystal structures that, together with prior structural knowledge, enable a comprehensive analysis of the classical PTP family. Despite their largely conserved fold, surface properties of PTPs are strikingly diverse. A potential secondary substrate-binding pocket is frequently f ... [truncated at 450 characters in length]|
|Author||Barr, Alastair J; Ugochukwu, Emilie; Lee, Wen Hwa; et al|