Out of the box binding determines specificity of SH2 domain interaction.
|Abstract||SH2 domains are phosphotyrosine specific interaction modules with largely overlapping sequence specificities. A recent structure by Bae et al. revealed that SH2 domain specificity can be mediated by secondary binding sites located outside the phosphotyrosine binding pocket.|
|Author||Müller, Susanne; Knapp, Stefan;|