Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites.
|Abstract||Protein kinase autophosphorylation of activation segment residues is a common regulatory mechanism in phosphorylation-dependent signalling cascades. However, the molecular mechanisms that guarantee specific and efficient phosphorylation of these sites have not been elucidated. Here, we report on three novel and diverse protein kinase structures that reveal an exchanged activation segment conformation. This dimeric arrangement results in an active ... [truncated at 450 characters in length]|
|Author||Pike, Ashley C W; Rellos, Peter; Niesen, Frank H; et al|