MAPK-specific tyrosine phosphatases: new targets for drug discovery?
|Abstract||Protein tyrosine phosphatases (PTPs) have key roles in a diverse range of cellular processes, and their dysregulation is associated with several human diseases. Many PTPs are recognized as potential drug targets; however, inhibitor development has focused only on a small number of enzymes, most notably PTP1B for type II diabetes and obesity, and MKP1 and CDC25 for cancer. The future challenge of selective-inhibitor development for PTPs will be si ... [truncated at 450 characters in length]|
|Author||Barr, Alastair J; Knapp, Stefan;|