Detecting activations in event-related fMRI using analysis of variance.
|Abstract||The most common design of a functional MRI (fMRI) experiment is a block design. The use of rapid imaging, however, and carefully designed paradigms makes the separation of cognitive events possible. Such experiments make use of event-related paradigms, in which a task involving several cognitive processes is repeated. In analyzing data from such experiments, existing methods often prove inadequate, because the prediction of the exact shape or tim ... [truncated at 450 characters in length]|
|Author||Clare, S; Humberstone, M; Hykin, J; et al|
Time-resolved fluorescence imaging for quantitative histochemistry using lanthanide chelates in nanoparticles and conjugated to monoclonal antibodies.
|Abstract||Tissue and cell examinations have a potential to produce extremely valuable information about antigen quantities in samples. Using currently available methods, a truly quantitative analysis is nearly impossible. We have previously shown that immunohistochemical (IHC) detection of prostate-specific antigen and human glandular kallikrein from prostatic tissue, together with time-resolved fluorescence imaging (TRFI), is a suitable method for obtaini ... [truncated at 450 characters in length]|
|Author||Väisänen, V; Härmä, H; Lilja, H; et al|
Statistics in medical journals: some recent trends.
|Abstract||I review some areas of medical statistics that have gained prominence over the last 5-10 years: meta-analysis, evidence-based medicine, and cluster randomized trials. I then consider several issues relating to data analysis and interpretation, many relating to the use and misuse of hypothesis testing, drawing on recent reviews of the use of statistics in medical journals. I also consider developments in the reporting of research in medical journa ... [truncated at 450 characters in length]|
A 31P-magnetic resonance spectroscopy and biochemical study of the mo(vbr) mouse: potential model for the mitochondrial encephalomyopathies.
|Abstract||31P-magnetic resonance spectroscopy (31P-MRS) provides new biochemical information on mitochondrial disorders affecting brain and muscle. To elucidate the mechanisms of mitochondrial abnormalities, however, animal models are needed. We assessed the mo(vbr) (mottled viable brindled) mouse for its value in studying (1) energetics of a mitochondrial disorder and (2) 31P-MRS changes associated with mitochondrial abnormalities in vivo. The maximal act ... [truncated at 450 characters in length]|
|Author||Tracey, I; Dunn, JF; Radda, GK;|
Specific role for cathepsin S in the generation of antigenic peptides in vivo.
|Abstract||To address the role of different proteases in degradation of antigen destined for MHC class II-restricted presentation, we generated cathepsin-deficient mice carrying a transgenic B cell receptor (BCR) specific for hen egg lysozyme (HEL). We demonstrate that degradation of HEL in B lymphocytes is highly processive and does not result in discrete processing intermediates. Moreover, degradation of HEL does not require initial unlocking of the antig ... [truncated at 450 characters in length]|
|Author||Plüger, EB; Boes, M; Alfonso, C; et al|