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     dc:creator "Bentley, Scott Alexander",
         "Davies, Stephen G.";
     dc:date "2011";
     dc:description "<p>This thesis is concerned with the asymmetric conjugate addition reactions of a range of chiral nucloeophiles.</p><p>Chapter 1 introduces the conjugate addition reaction as a valuable carbon-carbon and carbon-heteroatom bond forming reaction in organic chemistry, and explores the asymmet- ric conjugate addition of a range of chiral and achiral carbon and nitrogen nucleophiles to a range of acceptors.</p><p>Chapter 2 explores the use of the N-benzyl-N-(α-methylbenzyl)amino group as a chi- ral auxiliary, by employing the attempted conjugate additions of both N-benzyl-N-(α- methylbenzyl)hydrazine and N -benzyl-N -(α-methylbenzyl)hydroxylamine as chiral ammo- nia and water equivalents respectively.</p><p>Chapter 3 describes the asymmetric and stereoselective preparation of a range of 4,4- disubstituted isoxazolidin-5-ones from the conjugate addition of lithium (S)-N-<em>tert</em>-butyl- dimethylsilyloxy-N -(α-methylbenzyl)amide. The isoxazolidin-5-ones are then globally de- protected <em>via</em> hydrogenolysis, giving rise to the corresponding β<sup>2,2,3</sup>-amino acids.</p><p>Chapter 4 focuses on the development of a protocol to effect the conjugate addition of a chiral aniline equivalent. The scope of the reaction is delineated by varying both the nu- cleophile and the α,β-unsaturated ester. Finally, cyclisation of the β-N-arylamino esters to the corresponding tetrahydroquinolines is explored, and an application to the synthesis of the natural product (−)-angustureine is presented.</p><p>Chapter 5 contains full experimental procedures and characterisation data for all com- pounds synthesised in Chapters 2, 3 and 4.</p>";
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     dc:identifier "ora:6563",
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     dc:language "en";
     dc:subject "Organic synthesis",
         "asymmetric synthesis",
         "chemical methodology",
         "conjugate addition",
         "organic chemistry";
     dc:title "Asymmetric conjugate addition reactions";
     dc:type "text",
         "thesis";
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