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     dc:creator "Gerelle, Maria",
         "Willis, Michael C.";
     dc:date "2012";
     dc:description "<p>Chapter 1 is a brief literature review of the most recent progress in the area of C-H functionalization via palladium catalysis. This covers the functionalization of electron deficient arenes and heterocycles with alkenyl and alkyl halides both using inter- and intra-molecular reactions. The chapter also contains an overview of recent work from the Willis group.</p><p>Chapter 2 presents the functionalization of electron deficient arenes and alkenyl bromides using palladium catalysis, as well as the use of statistical analysis software for optimizing the cross-coupling reaction.</p><p>Chapter 3 describes the cross-coupling of substituted benzoxazoles, benzothiazole and benzimidazole with a range of alkenyl iodides using palladium catalysis. The reaction can tolerate both (E) and (Z) disubstituted alkenes and tri-substituted alkenyl iodides, with retention of the double bond geometry.</p><p>Chapter 4 details the synthesis of sultams via an intramolecular C-H functionalization using palladium catalysis. The chapter covers the optimization of the starting material synthesis as well as the cross-coupling reaction. We can access the sulfonamides from cyclohexenone and were able to incorporate a large range of substitution patterns (Scheme 3).</p><p>Finally, Chapter 5 contains all the experimental details, general considerations and compound data. All the NMR spectra of novel compounds can be found in the appendix.</p>",
         "This thesis is not currently available via ORA.";
     dc:format "born digital";
     dc:identifier "ora:6541",
         "urn:uuid:45d028d2-0548-4f22-a110-49aa97ae8dde";
     dc:language "en";
     dc:rights "Restricted: Full content available from 2015-09-28 (ISO 8601)";
     dc:subject "Catalysis",
         "Chemistry & allied sciences",
         "Heterocyclic chemistry",
         "Organic chemistry",
         "Organic synthesis",
         "chemistry",
         "heterocycles",
         "organic",
         "organic synthesis",
         "palladium-catalysis";
     dc:title "Synthesis and elaboration of heterocycles via palladium-catalyzed C-H functionalization";
     dc:type "text",
         "thesis";
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